Application of cfDNA fragmentation pattern analysis in liver transplantation and hepatocellular carcinoma (HCC) patients. (A) Correlation between OCF values for the liver and donor DNA fractions in liver transplantation patients; (B) tumor DNA fraction in HCC cases. (C) Comparison of OCF values for T cells; (D) the liver among healthy nonpregnant subjects and HCC cases (separated into two groups based on the tumor DNA load in plasma).