Global comparison of ROM and WGBS results in functional genomic elements. (A) Nonmethylation levels as a function of distance from histone modification peaks, for ROM and WGBS (blue indicates H3K4me3; red, H3K4ac). (B) Nonmethylation levels across gene bodies, in correlation with overall gene methylation level, determined by WGBS (red indicates low methylation level; blue, medium methylation level; gray, high methylation level). Gene lengths were normalized to 15 kbp, and 3 kbp was added upstream of the TSS and downstream from the TES.