TOR pathways provide resistance to CoCl₂. (A) Ontology of genes adjacent to competition-enriched Tf1 insertions are associated with TOR signaling, stress response, and cation transport. P-values based on hypergeometric tests were corrected per gene set by false-discovery rate. (*) P ≤ 0.05; (**) P ≤ 0.005. (B) Regulatory relationships of genes in the TOR pathways. Intracellular amino acid concentrations regulate TORC1 and TORC2, leading to the regulation of various downstream processes. Thirty-six genes shown in blue were adjacent to competition-enriched Tf1 insertion tags. Reproduction* indicates genes involved in mating and meiosis. (C) Growth phenotype on solid media containing CoCl₂ of cells lacking factors in TORC1 and TORC2 pathways.