Mechanism for chromosomal inversion with a repeated sequence motif. A hypothetical chromosome is shown with genes A through N and two repeated sequence motifs (open and black arrows) in a reverse orientation (top). Repeated motifs are shown pairing during meiosis with a recombination event occurring in the middle of the paired motifs (middle). Resolution of the recombination event between the repeated sequence motifs leading to the inversion of the central gene region (bottom).