Schematic representation of genomic events accompanying the origin of proximal CMT1A-REP. Between divergence of gorilla and chimpanzee, ∼3–7 Mya, an insertional duplication of the distal CMT1A-REP into LCR17pA resulted in a proximal CMT1A-REP copy. A 4960-bp genomic DNA fragment was deleted at the junction of the insertion site. The deleted fragment and corresponding DNA sequence are shown in red. Note that this 4960-bp fragment is still present in the human LCR17pB copy, which was duplicated earlier from LCR17pA, between orangutan and gorilla, 7–12 Mya, thus reflecting the structure of the ancestral LCR17pA copy.