Comparison of genomic location of the homologous ORFs in GAS strains SSI-1 (M3) vs. SF370 (M1), SSI-1 vs. MGAS8232 (M18), and SSI-1 vs. MGAS315 (M3) (A), in GAS strains SF370 (M1) vs. MGAS8232 (M18) and SF370 vs. MGAS315 (M3) (B), in GAS strains and Streptococcus pneumoniae (C), or S. agalactiae 2603V/R (D). Pairs of homologous ORFs between two strains were generated by BLASTP analysis (E<1.0 × 10^-5). The homologous ORFs on each chromosome are shown by connected green lines (the relative location of each ORF is conserved) or red lines (the relative location of each ORF is in the opposite direction). The blue line indicates the putative region of the replication terminus (ter).