Probability of closure as a function of depth of coverage for various projects: 1. Zhu et al. (1999); 2. Dewar et al. (1998); 3. Fleischmann et al. (1995); 4. McPherson et al. (2001); 5. Adams et al. (2000); 6.Venter et al. (2001). Abbreviations “f.p.” and “w.g.s.” represent fingerprint mapping and whole genome shotgun sequencing projects, respectively. Cases 1 and 2 were evaluated using equation 4, whereas the remaining cases were determined using equation 9.