Multiple enhancer variant loci are a common feature of many GWAS traits. (A) Hierarchical clustering of disease traits based on the number of SNPs that intersect with H3K4me1 sites linked to a gene target with PreSTIGE. Cluster of disease traits that correlate with SNPs present in HepG2 (B) and NPC (C) predicted enhancers (zoomed image HepG2 and NPC clusters in A). Genes predicted to be targeted by the disease-correlated SNPs are shown to the right. Columns are ordered as shown in A. (D) Percent of GWAS enhancer loci that involve multiple enhancer variants for each cluster highlighted in A.