Transcription levels at ORC1 peaks correlate with replication timing. (A) Boxplots of the transcription levels measured at ORC1 peaks replicating in the S1–S6 windows. (B) Frequency of early (S1 + S2), middle (S3 + S4), or late (S5 + S6) replicating ORC1 peaks within groups with homogenous expression (<1, 1–10, or ≥10 RNA copies/cell). (C) Frequency of ORC1 peaks with different transcription levels (<1, 1–10, or ≥10 RNA copies/cell) within groups of ORC1 sites homogeneous for replication timing. (D) Boxplots of the s50 values of ORC1 peaks with different transcription levels (<1, 1–10, or ≥10 RNA copies/cell) mapping within very-early-replicating (S1) inverted-V apexes. (E) Boxplots of the transcription levels measured at the ORC1 peaks mapping within proximal promoters of known genes, intragenic, or intergenic regions, as indicated. (F) Frequency of ORC1 peaks with different transcription levels (<1, 1–10, or ≥10 RNA copies/cell) for each genomic location, as indicated. (G) Frequency of early (S1 + S2), middle (S3 + S4), or late (S5 + S6) replicating ORC1 peaks for each genomic location, as indicated.