Summary of somatic genomic alterations in HCC patients. Various types of somatic alterations in the four HCC patient genomes using circos plots (Krzywinski et al. 2009) (A–D). High confidence somatic structural variations (SVs) are shown as lines, with red lines representing interchromosomal SVs and blue lines indicating intrachromosomal SVs. (Green bars) Regions of loss of heterozygosity and allelic imbalance. Somatic copy number alterations are shown as bar plots with copy number gain shown in red and copy number loss in blue (the scale ranges from −2 to 4). Each surrounding red dot represents the number of high-confidence somatic SNVs within a 1 million base pair window. (Triangles) Major HBV integration sites. Patient's identifier and HBV status are shown at the center of each circular view.