ISMARA predicts TFs involved in recruiting specific chromatin marks. (A) Activity across cell types of the SNAI1..3 motif in explaining expression (black), and levels of the chromatin marks H3K4me3 (dark green), H3K4me2 (light green), H3K9ac (dark blue), H3K27ac (light blue), and H3K36me3 (brown). (B) First principal component explaining the majority of variation in chromatin mark levels across all cell types. The bars indicate the relative contributions to the principal component of each mark. (C) Motif activities of the SNAI1..3 motif, as in A, but after removal of the first principal component. (D) Z-values and specificities (see text) of motifs for explaining H3K27me3 levels. The REST motif, with both highest Z-value and highest specificity, is indicated in red. (E) As in D, for H3K9ac levels. The two most significant motifs are shown in red. (F) As in D and E, for H3K27ac levels. (G) Activity, after removal of the first principal component, of the RFX motif for explaining H3K9ac (dark blue) and H3K27ac (light blue) levels. (H) As in G, for the ATF5_CREB motif.