Observed and expected frequencies of common regulatory elements, the GGG trinucleotide and the CpG dinucleotide, in a typical human gene. The model gene contains information combined from all known genes in the entire human genome. The expected frequencies are calculated from local individual nucleotide frequencies, corrected for biases in occurrence of GGG and CpG in noncoding genomic regions. The slider bar at the bottom of each graph indicates the regions of relative over- and underrepresentation of each motif. Excess of a given motif over the expected frequency indicates a possible regulatory function.