Mucociliary differentiation. (A) Inferred RFX motif activity profile in mucociliary differentiation of bronchial epithelial cells from three independent donors (black, red, and blue lines). (B) Key predicted regulators and their targets in this system. Selected top motifs are shown together with predicted interactions between them and pathways/functional categories that are enriched among predicted targets of these motifs. The intensity of the color corresponds to the Z-score of the motif, its time-dependent activity for each donor is indicated inside the node, and the thickness of the edges corresponds to the target score S_pm. (C) mRNA expression profiles of the RFX2 (solid) and RFX3 (dashed) genes across the differentiation (colors of the donors as in A).