Pathways, processes, and diseases associated with the CNC transcriptome data set. Biological pathway analysis shows enrichment of migrating cranial crest genes involved in integrin (A) and CXCR4 (B) signaling, as expected since both signaling systems are essential for neural crest migration. This analysis also reveals potential roles for post-translational regulation in CNC development as a large number of molecules involved in RNA splicing and processing are up-regulated (C). (D) Genes involved in diseases such as osteochondrodysplasia are present in the data set, which is consistent with the contribution of the neural crest to the craniofacial skeleton. (E) Enrichment of CNC genes in other pathways, processes, and diseases.