Sequence context for base substitutions observed in cisplatin-treated C. elegans. (A) Surrounding sequence context for cytosine and thymine substitutions in animals exposed to cisplatin, split by type of mutation. The genomic sequence from three bases upstream to three bases downstream from each observed mutation was aggregated and presented as proportions in a stacked bar chart, compared to the reference genome. (B) Surrounding sequence context for cytosine and thymine substitutions in animals exposed to cisplatin, split by genetic background. The genomic sequence from three bases upstream to three bases downstream from each observed mutation was aggregated and presented as proportions in a stacked bar chart, compared to the reference genome.