Coevolution of ABC transporter (A) and information processing (B) families. Gray lines correspond to the KEGG-based COG network constructed from genes, i.e., a link is colored gray when both COGs have a gene in the same pathway. In panel A the large cluster corresponds to the general KEGG group of ABC transporters, while the ribosome is shown in panel B. Links colored in orange are TP, i.e., links that are both in the KEGG-based COG network and in the coevolution map. Green links are false positives, links that are only in our coevolution map.