Experimental design for genotyping studies and thermal dissipation effects of added fins. (A) For hybridization experiments, islands were controlled so that their temperatures increased monotonically in adjacent columns. Normal and mutant probes for a given allele were placed in duplicate in adjacent rows. (B) When heat dissipation fins were constructed between islands, the thermal isolation between adjacent islands was significantly improved. (mathematical simulation; cf. Fig. 3A and refer to text for details)