Cranial neural crest transcriptome data set reveals hundreds of genes up-regulated in cranial neural crest cells. (A) Our transcriptome analysis identified 1301 genes significantly up-regulated in the migratory cranial crest, and 257 genes that were excluded from this population. (B) Genes enriched in CNC. The largest fraction are enzymes, followed by transcriptional regulators and transporter molecules. (C) Transcription factors known to be important players in the migratory neural crest are among the enriched genes in the CNC transcriptome data set. (D) Most enriched and depleted genes in the cranial neural crest. SOX10 and SOX8 are among the genes that are the most enriched in the cranial neural crest, whereas several HOX genes are absent from this anterior cell population, as expected.