Multiple sequence alignment of predicted nucleases associated with the hypothetical EP-ADDL-Ku repair system. The novel potential nuclease (A) and The URI-domain-containing nuclease (B). The potential metal chelating and active site residues are shown in reverse red shading. (B) The K7M2.9 from Arabidopsis is fused to a MutS domain at the amino terminus, whereas the other eukaryotic forms show carboxy-terminal fusion to a PHD fingers. The species abbreviations are as in Figure 2; the additional abbreviations not present in Figure 2 are: Nc, Neurospora crassa; AcNPV,Autographa californica Nuclear polyhedrosis virus; Ngo,Neisseria gonorrhea; Bs, Bacillus subtilis; Ec,Escherichia coli; Ccr, Caulobacter cresentus.