Schematic diagram of the human chromosome 4q11–q21 region deduced from P1/PAC and YAC contigs. (A) The order of markers determined from previous (Stanford Human Genome Center; Karrman et al. 1997) and present data are shown. The distances between the markers are not drawn to scale, and the orders of STS markers enclosed by parentheses were not determined. Markers are indicated without the D4S designation. The angled arrows indicate the transcriptional directions of the genes. (B) Contigs of bacteriophage P1/PAC clones in the DBPgene region and in region of the ALB/AFP/AFM gene cluster isolated for this study. (C) YAC contig linking theDBP gene with the ALB/AFP/AFM gene cluster from previous (Stanford Human Genome Center; Karrman et al. 1997) and present data. The sizes of each YAC clone are indicated in parentheses. All the markers shown were tested for each YAC. A solid circle indicates the presence of the STS or the gene shown in A. An open circle indicates that the presence of that marker could not be confirmed in our experiments. An asterisk (*) indicates that our results were discrepant with the literature.