Sequence from two representative cell lines. (Left) Cell line 9072 (DQ4, DQB1*0402, DQCAR117); (right) cell line 9062 (DQ1, DQB1*0603, DQCAR103). The left arrow points to the A nucleotide interrupting the CA repeat sequence in the DQ1 cell line. Note the tetramer GCAA between the (CA) _n region and the (GA)5 in the DQ4 cell line. The right arrow points to the G substitution in the flanking region, characteristic ofDQCAR103 and DQCAR107. Sequence of opposite strand confirmed the results in both cases (not shown). Sequence was performed as detailed in Methods.