CNV hotspots correspond to CFSs. (A) Counts of 090 CNVs from 223 cell clones and CFS breaks from 100 metaphases at the nine 090 CNV hotspots. Correspondence to known CFSs is indicated: (*) CFS location previously characterized by FISH; (**) CFS location characterized by FISH in Figure 5; (–) no known CFS. (B) Chr 3 and the 3q13.31/LSAMP hotspot/CFS. Symbols above and below the ideogram denote 090 CNVs and CFS breaks, respectively. CFSs are marked in the middle of the corresponding band, or with a bracket indicating multiple possible source bands. 3q13.31 fragile site boundaries are from Le Tallec et al. (2011). See Supplemental Figure S2 and Supplemental Table S4 for complete CFS-CNV data.