(A) Genomic distribution of F_ST between AAF and YRI. (B) Genomic distribution of F_ST between AfA and rAfA. Dashed red horizontal line indicates the cutoff threshold (99.99th percentile). Locus-specific F_ST between YRI and CEU were calculated when MAF > 0.05 in both populations. The rAfA was constituted according to the ancestry proportion of CEU and YRI under neutrality.