Fine-mapping and validation of the serine racemase (17p13.3) locus. (A) The serine racemase (SRR) gene located on chromosome 17 was fine-mapped and re-sequenced; (B) the SNPs were associated with expression levels of SRR in 94 cultured human osteoblasts. (C) The P-values from linear regression analysis represented as –log10(P-value) are shown as vertical bars with a horizontal line indicating a cutoff of P = 10⁻⁴. SNPs in close LD with rs1885987 showing the most significant association with SRR expression are marked in red. (D) The HapMap PhaseII CEU LD blocks are shown as a diamond-shaped plot using log odds (LOD) measures.