Transcript map of 2.8-Mb region containing the MEN1 locus in the interval D11S480–D11S913. (A) The MEN1interval identified by linkage analysis spanning from D11S1883to D11S449 is shown, with the region from PYGM toD11S4936 marked by arrows as the minimal interval inferred from LOH data. The arrow with a dotted line represents the boundary determined from a sporadic gastrinoma. (B) The 1-Mb region from PYGM to D11S4933 is expanded for clarity. Some relevant markers are indicated above the map and the transcripts are identified below. Sizes of BAC clones (b137C7, b79G17, and b18H3) are given. Sequence contigs from cosmids C1, C2, and C3 are 14 kb, 46 kb, and 6.8 kb, respectively. (*) Genes that have been eliminated as MEN1 candidates by mutation detection analysis. Mutation analysis is incomplete for the Kappa and Eta (**). Identification and mapping of OVO will be reported independently (A. Chidambaram, R. Allikmets, S.C. Chandrasekharappa, S.C. Guru, W. Modi, B. Gerrard, and M. Dean, in prep.).