The ALL quartet family pedigree. The ALL quartet is composed of the two parents and two brothers (patients 383 and 610) affected by hyperdiploid B-cell precursor childhood ALL, sampled prior to and after chemotherapy treatment. The brothers were diagnosed within a 3-yr time period. The parents report Moroccan origins. Both maternal and paternal grandfathers are deceased from cancer. One of the father's sisters had children with poly-malformation syndromes, likely due to the high degree of consanguinity reported. Age at death is shown for deceased individuals.