ESR1 binding is induced by GEN and BPA. Examples of ESR1 binding induced by E2, GEN, BPA, and DMSO near the promoters of GREB1 (A) and JUND (B) in ECC-1 are shown. The height of the orange graph represents number of reads per 1 million total reads. (C) Binding site signal strength is plotted for each binding site with E2-induced signal strength (replicate 1) on the x-axis vs. E2 (black; replicate 2), GEN (green; replicate 1), and BPA (red; replicate 1) signal strength on the y-axis for ECC-1.