(See pages 693–695.) RH map of the domestic cat and human RH comparative map. Ideograms for each cat chromosome (Cho et al. 1997d) are shown to the left of each map. Hybridization results from human on cat chromosome painting (Rettenberger et al. 1995; Wienberg et al. 1997) are depicted to the left of each ideogram for comparison to the RH-derived syntenies. The extent of RH-based physical coverage of each chromosome is not implied, except where indicated by cytogenetic localization of Type I markers on the RH map (Cho et al. 1997a–c, 1998; Lee and Cho 1999). Orientation of RH maps relative to the chromosome is established except for the following chromosomes: D1, E3, F1, and Y. Green arrows indicate the inferred position of the centromere on the RH map, as determined by maximum retention frequency-based centromeric effects and syntenic boundaries. Loci labeled in red were ordered at odds ≥1000:1, those in blue ⩾100:1, those in black <100:1. The distances on the cat RH map are represented by alternating black and red vertical bars, with each bar corresponding to 50 cR5000. The length of each feline RH linkage group is listed below each map. The human RH maps are shown on the right. RH coordinates for the outermost markers of each human conserved homology block are listed. Human loci positioned on the Stanford G3-based RH map are depicted by a bar spanning the range of the same map interval in the Genebridge-4-based RH map (see Methods). Human ESTs that have not been associated with a named gene of known function are listed by their UniGene cluster identifier. Feline homologs of these loci are indicated by the prefix Fc. preceding the human cluster identifier number. The majority of feline microsatellites are denoted by the prefix FCA or an F, followed by a number (Menotti-Raymond et al. 1999). Broken lines connect homologous Type I loci in both cat and human RH maps. Gaps in the RH maps of B3 and E1 are connected by broken lines (no distance implied) and are bracketed by linked microsatellite loci in the genetic linkage map (Menotti-Raymond et al. 1999).
