Methylation at known maternally imprinted gene clusters. Differentially methylated ICRs are evident for all maternally imprinted clusters in both somatic and extraembryonic tissues. Individual panels represent DMRs of each cluster as titled. (A) IGF2R intronic DMR. (B) INPP5F_v1 is biallelically expressed with an unmethylated promoter and is shown alongside the imprinted INPP5F_v2 for comparison. (C) KCNQ1 DMR. (D) NAP1L5 DMR. (E) PEG3 DMR. (F) SNRPN DMR (PWS-IC). (G) PLAGL1 DMR. SNPs around each DMR were used to make the allelic distinctions shown.