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Genome Research 12: 527–530 (2002)

Functional Diversity of Mx Proteins: Variations on a Theme of Host Resistance to Infection

Seung-Hwan Lee and Silvia M. Vidal

In the reproduction of Table 1. Intracellular Localization and Antiviral Spectrum for Selected MX Proteins, the first column (Species) was truncated. The corrected table has been reprinted in its entirety here.

Table 1.

Intracellular Localization and Antiviral Spectrum for Selected Mx Proteins

Species Gene Accession no. Size (aa) Intracellular localization Antiviral specificity
Virus Family
Human MxA P20591 661CytoplasmInfluenza virus, Thogoto virus Orthomyxoviridae 1
Vesicular stomatitis virus Rhabdoviridae 2
Measles virus Paramyxoviridae 3
Hantaan virus Bunyaviridae 4
Coxsackievirus B4 Picornaviridae [iii]
Semliki Forest virus Togaviridae [iv]
MxB P20592 715Nucleus and cytoplasmInactive
Mouse Mx1 P09922 631NucleusInfluenza virus, Thogoto virus, Dhori virus Orthomyxoviridae 1
Mx2 NP_38634655CytoplasmVesicular stomatitis virus Rhabdoviridae 2
Hantaan virus Bunyaviridae 4
Rat Mx1 P18588 652NucleusInfluenza virus, Thogoto virus Orthomyxoviridae 1
Mx2 P18589 659CytoplasmVesicular stomatitis virus Rhabdoviridae 2
LaCrosse virus, Rift Valley fever virus Bunyaviridae 4
Mx3 P18590 659CytoplasmInactive
Chicken Mx Q92597 705CytoplasmInfluenza virus Orthomyxoviridae 1
Vesicular stomatitis virus Rhabdoviridae 2
Duck Mx P33238 721Nucleus and cytoplasmInactive

[i] 1,4Enveloped, negative-sense segmented RNA virus

[ii] 2,3Enveloped, negative-sense non-segmented RNA virus

[iii] Naked, positive-sense non-segmented RNA virus

[iv] Enveloped, positive-sense, non-segmented RNA virus

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