Model performance in predicting BIS scores
| Performance metric | BIS scores (R2) |
|---|---|
| ADHD-PRS | 14.8% |
| Elastic Net | 6.5% ± 2.1% |
| ePRS | 17.8% ± 2.3% |
[i] ePRS significantly outperforms elastic net while achieving comparable standard error across 50 different train-test splits of the target data set. R2 represents the proportion of variance in BIS scores explained by the various polygenic scores. ADHD-PRS performs comparably well, potentially owing to R2 being driven by a few variants with large effect sizes. (ADHD) Attention-deficit/hyperactivity disorder, (BIS) Barratt impulsiveness scale.