Table 4.

Model performance in predicting BIS scores

Performance metricBIS scores (R2)
ADHD-PRS14.8%
Elastic Net6.5% ± 2.1%
ePRS17.8% ± 2.3%

[i] ePRS significantly outperforms elastic net while achieving comparable standard error across 50 different train-test splits of the target data set. R2 represents the proportion of variance in BIS scores explained by the various polygenic scores. ADHD-PRS performs comparably well, potentially owing to R2 being driven by a few variants with large effect sizes. (ADHD) Attention-deficit/hyperactivity disorder, (BIS) Barratt impulsiveness scale.