Table 2.

Fifty visible phenotypes and candidate mutations

MutationStrain name(s)Mutation typeOriginReferenceDescription
ac16027LSV/deletionSpontaneousCampuzano et al. 19852.8 kb deletion, located 5.8 kb upstream of ac
Adcb-1156IndelSpontaneousPhillips et al. 20054 bp replaced by an 8 bp insertion in coding sequence; nonsynonymous SNP
al1156IndelSpontaneousUncharacterized10 bp deletion of coding sequence
ast11349LSV/TE insertionSpontaneousUncharacterized, but mutation type predicted by Higson et al. (1993)Duplication of 6.4 kb region containing complete asteroid gene, copies separated by 33.8 kb insertion of HMS-Beagle, gypsy, and roo elements
c1156LSV/TE insertionSpontaneousUncharacterized7.5 kb DM412 element inserted in coding sequence
ca1576SSV/deletionSpontaneousMa et al. 200414 bp deletion of coding sequence
car16027SNPX-raySevrioukov et al. 1999Nonsynonymous SNP
cl11349LSV/TE insertionSpontaneousGiordano et al. 20037.4 kb blood element inserted in coding sequence
cm11282, 1570, 6027LSV/TE insertionSpontaneousMullins et al. 19999.2 kb roo element inserted in coding sequence
cp1620SNP/indelSpontaneousUncharacterizedPotentially a 7 bp indel near a regulatory site in CG5151
ct16027LSV/TE insertionSpontaneousUncharacterized7.3 kb gypsy element inserted in wing enhancer
ct61570LSV/TE insertionSpontaneousTchurikov et al. 1989; Dorsett 19937.3 kb gypsy element inserted in wing enhancer
cu1576IndelSpontaneousGrönke et al. 2009Substitution of 2 bp at splice acceptor site
Diap1th-1576SNP/indelSpontaneousUncharacterized576 and 620 do not share any unique mutations in or near the gene; both have indels/SNPs in close proximity located in an intron, a putative enhancer region
620
dppd-ho1349LSV/deletionSpontaneousMasucci et al. 19903066 bp deletion, 22.7 kbp from 3′ end of dpp
dpyov1156, 1349LSV/TE insertionSpontaneousCarmon et al. 20107.4 kb blood element intronic insertion
dy11570LSV/deletionspontaneousDiBartolomeis et al. 2002358 bp deletion, 1.8 kb from start of dy; 464 bp deletion, 2.7 kb from start of dy
es554, 576SNPSpontaneousUncharacterizedNonsynonymous SNP
ed11349LSV/TE insertionSpontaneousUncharacterized7.8 kb intronic insertion of gypsy and Stalker elements
f11570LSV/duplicationSpontaneousNew allele2.7 kb duplication of coding exon and intronic sequence
5295, 6027LSV/TE insertionHoover et al. 19937.4 kb gypsy element intronic insertion
g16027LSV/TE insertionSpontaneousUncharacterized, but mutation type predicted by Lloyd et al. (1999)7.4 kb blood element intronic insertion
g21570, 5295SNP/indelSpontaneousUncharacterized, but mutation type predicted by Lloyd et al. (1999)3 bp in-frame deletion, nonsynonymous SNP
hry1576LSV/TE insertionSpontaneousHooper et al. 19897.4 kb gypsy element insertion, 4.8 kb from start of hry
in1620SNPSpontaneousUncharacterizedNonsynonymous SNP
kniri-1620LSV/deletionSpontaneousLunde et al. 2003253 bp deletion of regulatory sequence, 11.7 kb from start of kni
m16027SSV/indelSpontaneousRoch et al. 200311 bp deletion of coding sequence
m74f1282IndelEthyl methanesulfonateUncharacterized1 bp deletion, 3 bp intronic insertion
oc11570LSV/inversionX-raySpradling et al. 1979; Spradling and Mahowald 1981154 kb inversion, including oc gene
pp620SNPSpontaneousFalcón-Pérez et al. 2007; Syrzycka et al. 2007)Nonsynonymous SNP
pn11570, 6027LSV/TE insertionSpontaneousFrolov et al. 1994; Timmons and Shearn 19967.5 kb DM412 element inserted in coding exon
pr1156LSV/TE insertionSpontaneousKim et al. 19967.5 kb DM412 element intronic insertion
px1156LSV/DuplicationSpontaneousUncharacterizedPartial duplication of coding exon with copies separated by 7.4 kb DM412 element
ras21570LSV/TE insertionSpontaneousLocation and size approximated by Nash et al. (1994)5 kb blastopia intronic insertion
ras46027LSV/TE insertionSpontaneousUncharacterized, might be misgenotyped, same mutation as ras25 kb blastopia intronic insertion
rb16027LSV/TE insertionSpontaneousUncharacterized7.8 kb insertion of gypsy and Stalker elements into coding exon
ru1576SNPSpontaneousYu et al. 2010Premature stop codon
sc16027LSV/TE insertionSpontaneousCampuzano et al. 19851.6 kb gypsy, 7 kb from start of sc
sd11282SSV/deletionX-rayUncharacterized22 bp deletion of coding sequence
sn35295, 6027LSV/deletionSpontaneousPaterson and O'Hare 1991292 bp deletion from 5′ UTR
speck1156LSV/TE insertionSpontaneousChakraborty et al. 2019; Spana et al. 20207.5 kb DM412 element inserted into intron, present in ISO-1 reference
sr1554, 576SNPSpontaneousUncharacterized576 and 554 share four SNPs in 5′ UTR and three intronic SNPs
st1576, 620LSV/TE insertionSpontaneousten Have et al. 19957.4 kb DM412 element inserted in coding exon
svde662LSV/TE insertionSpontaneousFu et al. 19985 kb Tirant 1.6 Kb from 5′ end of gene
Ubxbx-1554LSV/TE insertionSpontaneousBender et al. 1983; Castelli-Gair and García-Bellido 19907.5 kb DM412 element insertion into intronic regulatory element
Df(1)os-o(upd1os-o,upd3os-o)1570LSV/deletionX-rayWang et al. 20143.1 kb deletion upstream of upd3
Ab(1)os-s(upd1os-s,upd3os-s)1282SNP/IndelSpontaneousUncharacterizedNonsynonymous SNP and 3 bp in-frame deletion of coding sequence in upd3
v11570, 5295, 6027LSV/TE insertionSpontaneousSearles et al. 19907.5 kb DM412 element inserted in 5′ UTR
w11570, 6027LSV/TE insertionSpontaneousDriver et al. 19894.7 kb Doc element insertion, 17 bp from start of w
w11185295LSV/TE insertionSpontaneousHazelrigg et al. 19844.7 kb Doc element insertion, 4 kb copia within Doc element, 17 bp from start of w
y16027LSV/insertionSpontaneousNew allele622 bp insertion in coding exon, introduces premature stop codon
1570, 5295SNPGeyer et al. 1990Start codon loss caused by SNP