Model performance (AUC) in distinguishing JME individuals from UKBB controls
| Performance metric | JME v. UKBB controls (AUC) |
|---|---|
| IGE-PRS | 0.74 |
| Pruning and thresholding | 0.78 |
| Elastic net | 0.848 ± 0.043 |
| ePRS | 0.874 ± 0.021 |
[i] The ePRS significantly outperforms both IGE-PRS and pruning and thresholding and demonstrates greater stability in model performance across 50 different train-test splits derived from the original target cohort (JME individuals and UKBB controls). (AUC) Area under the curve, (IGE) idiopathic generalized epilepsy, (JME) juvenile myoclonic epilepsy, and (UKBB) UK Biobank.