Analysis of ChromMovie performance on mitotic chromosome formation. (A) Original Hi-C contact matrices (top row) and simulation distance matrices (bottom row) from eight time points of mitotic chromosome formation. Region consists of chicken Chr 4: 1–2,000,000. (B) Spearman's correlation of the original Hi-C matrix of a whole chicken Chromosome 4 and the model's inverse distance matrices. Different levels of weighted logarithm down-sampling are present from 100% representing all of the contacts retained to 10%. (C) Spearman's correlation of the ensemble inverse distance matrices to the original Hi-C (dark green). Spearman's correlation of the 20 individual inverse distance matrices to the original Hi-C (olive-green).