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Table 1.

Candidate Gene Screening Panels

Candidate gene	STS	Size range	Chromosomal location	Type of repeat	Dye
Candidate Panel 1
Leptin	D7S530	106–118	7q31–35	2	FAM
CPE	D4S417	174–186	4pter–qter	2	FAM
β-3AR	D8S1803	266–288	8pter–qter	2	FAM
Leptin	D7S514	147–157	7	2	TET
NPY Y5R	D4S1603	190–208	4pter–qter	2	TET
POMC	D2S171	253–281	2p24–p21	2	TET
UCP2	D11S916	135–153	11q13–q23	2	HEX
β-3AR	D8S1791	225–243	8pter–qter	2	HEX
ART	D20S106	316–322	20	2	HEX
Candidate Panel 2
NPY Y5R	D4S3046	93–103	4pter–qter	2	FAM
tub	D11S932	150–164	11p15.4–15.1	2	FAM
PPARγ	D3S3610	249–263	3	2	FAM
Ob-R	D1S198	308–322	1p32	2	FAM
tub	D11S909	113–125	11p15.4	2	TET
PPARγ	D3S3701	171–179	3	2	TET
ART	D16S496	209–226	16q22.1	2	TET
Ob-R	D1S2866	277–287	1p32	2	TET
PPARγ	D3S3602	114–132	3	2	HEX
CPE	D4S1566	197–209	4pter–qter	2	HEX
UCP2	D11S4207	256–282	11pter–qter	2	HEX
Candidate Panel 3
NPY	D7S673	118–148	7p22–p21	2	FAM
MC4R	D18S64	188–208	18q21.32	2	FAM
NPY	D7S682	271–283	7pter–qter	2	FAM
NPY Y6R	D5S1983	112–122	5	2	TET
NPY Y6R	D5S414	186–206	5	2	TET
ART	D16S3019	240–254	16pter–qter	2	TET
PC 1	D5S644	81–101	5	2	HEX
APOJ	D8S137	152–162	8p21.3–q11.1	2	HEX
ART	D16S400	192–202	16q21	2	HEX
PC 1	D5S484	261–281	5	2	HEX
Candidate Panel 4
POMC	D2S2170	130–134	2qter	2	FAM
POMC	D2S144	152–200	2p24–p21	2	FAM
leptin	D7S635	216–234	7	2	FAM
ART	D16S3021	156–174	16pter–qter	2	TET
POMC	D2S2168	199–229	2qter	2	TET
Ob-R	D1S2852	246–278	1p31	2	TET
APOJ	D8S1809	154–174	8	2	HEX
tub	D11S1331	191–205	11p15.4–15.1	2	HEX
β-3AR	D8S1791	225–243	8qter–pter	2	HEX
Candidate Panel 5
MC4R	D18S1357	126–147	18q21.32	4	FAM
NPY Y6R	D5S816	225–253	5	4	FAM
NPY Y5R/CPE	D4S3339	267–283	4pter–qter	4	FAM
NPY	D7S1821	308–324	7pter–qter	4	FAM
NPY	D7S2190	134–149	7pter–qter	3	TET
PC 1	GATA3H06	195–241	5	4	TET
β-3AR	D8S2317	283–295	8	4	TET
UCP2	D11S2371	193–213	11pter–qter	4	HEX
MC4R	GATA89B12	260	18q21.32	4	HEX

Obesity syndrome	STS	Size range	Chromosomal location	Type of repeat	Dye
Syndrome Panel 1
CS	D8S257	106–122	8q22.2	2	FAM
BBS2	D16S419	146–164	16q12.1	2	FAM
PW	D15S128	193–209	15q11–13	2	FAM
BBS4	D15S204	116–134	15q22.3–23	2	TET
SS	D12S79	150–180	12	2	TET
PW-paternal	D15S156	217–229	15q11–13	2	TET
BBS3	D13S1251	125–139	3p11–q11	2	HEX
BBS4	D15S125	157–169	15q22.3–23	2	HEX
CS	D8S559	218–230	8q22.2	2	HEX
Syndrome Panel 2
BBS1	D11S987	82–118	11q13.1	2	FAM
BBS3	D3S1271	146–158	3p11–q11	2	FAM
BBS1	D11S480	189–201	11q13.1	2	FAM
BBS1	D11S913	220	11q13	2	FAM
PW	D15S210	130–146	15q11–13	2	TET
BBS4	D15S114	177–187	15q22.3–23	2	TET
BBS4	D15S131	238–274	15q22.3–23	2	TET
AS	D15S122	143–159	15q11.2–13	2	HEX
BBS2	D16S408	241–251	16q13	2	HEX

[i] Candidate screening panels 1–4 contain dinucleotide repeat polymorphic microsatellite markers for obesity candidate genes. There are six separate subheadings within each panel. Under Candidate gene, the gene for which the STS is a marker is identified. Under STS, the Whitehead designated name of the microsatellite is listed. Under size range, the established CEPH expected size range for the STS is listed. Under chromosomal location, the most precise chromosomal address as indicated in the Genome Database is listed. All polymorphic markers included in panels 1–4 are dinucleotide repeats. Under Dye, the recommended fluorescent dye used to label the STS and maximize the power of the technology is listed. Obesity candidate screening panel 5 and Syndrome panels 1 and 2 are named. Candidate panel 5 contains all tetranucleotide repeat STS, with the exception of D7S2190, which is a trinucleotide repeat microsatellite. Under Obesity syndrome, (panels 1 and 2) the obesity-related syndrome is listed for which the individual markers are used to assay.