Table 4.

Possible Origin of Analogous Enzymes by Recruitment of Enzymes with Related Activities

Enzyme (EC No.)Analogous enzymesHomologous enzymes with different activities (EC no., example)
Fructokinase  (EC2.7.1.4)SCRK_ECOLIribokinase  (EC 2.7.1.15, RBSK_ECOLI)
SCRK_ZYMMOglucokinase  (EC 2.7.1.2, GLK_STRCO)
6-PhosphofructokinaseK6P1_ECOLIPPi-dependent 6-phosphofructokinase
 (EC 2.7.1.11) (EC 2.7.1.90, PFPB_SOLTU)
K6P2_ECOLI1-phosphofructokinase  (EC2.7.1.56, K1PF_ECOLI)
ribokinase  (EC 2.7.1.15, RBSK_ECOLI)
Gluconokinase  (EC2.7.1.12)GNTK_ECOLI—
GNTK_BACSUglycerol kinase  (EC 2.7.1.30, GLPK_ECOLI)
Phosphatidylserine synthasePSS_ECOLI—
 (EC2.7.8.8)PSS_YEASTphosphatidylglycerophosphate synthase  (EC2.7.8.5, PGSA_ECOLI)
β-GalactosidaseBGAL_ECOLIβ-glucuronidase
 (EC3.2.1.23) (EC 3.2.1.31, BGLR_HUMAN)
BGAL_HUMANβ-glucosidase  (EC 3.2.1.21, BGLA_THEMA)
Apyrase, ATP-APY_AEDAE5′-nucleotidase
 diphosphatase (EC3.1.3.5, 5NTD_HUMAN)
 (EC 3.6.1.5)APY_SOLTUnucleoside triphosphatase  (EC 3.6.1.15, NTPA_PEA)
1546841[i] inositol-1,4,5-triphosphate 5-phosphatase  (EC 3.1.3.56, IT5P_HUMAN)
Diadenosine 5′,5′“-tetraphosphataseAP4A_HUMANNTP pyrophosphohydrolase
 (EC 3.6.1.17) (EC 3.6.1.-, NTPA_ECOLI)
APH1_SCHPOATP adenylyltransferase  (EC2.7.7.53, APA1_YEAST)
Tagatose 1,6-bisphosphate aldolaseAGAY_ECOLIfructose bisphosphate aldolase
 (EC4.1.2.40) (EC 4.1.2.40, ALF_ECOLI)
LACD_LACLA—
Phosphoglycerate mutasePMG1_ECOLIfructose 2,6-bisphosphatase
 (EC5.4.2.1) (EC 3.1.3.46, F26−YEAST)
PMGI_BACSUphosphopentomutase
PMGI_TOBAC (EC5.4.2.7, DEOB_BACSU)
alkaline phosphatase
 (EC3.1.3.1, PPB_ECOLI)
Lysine-tRNA ligaseSYK1_ECOLIaspartate-tRNA ligase
 (EC6.1.1.6) (EC 6.1.1.12, SYD_HUMAN)
2645489[ii] cysteine-tRNA ligase  (EC6.1.1.16, SYC_ECOLI)

[i] Apyrase from Rhodnius prolixus (Sarkis et al. 1986).

[ii] Lysine–tRNA ligase from Methanococcus maripaludis (Ibba et al. 1997b).