Dissimilar Enzymes Catalyzing the Same Biochemical Reactions[i]
| Enzyme activity (EC No.) | Taxonomic representation[ii] | PDB entry | Structural folds[iii] | ||||
| bacteria | archaea | eukaryotes | |||||
| Alcohol:NADP dehydrogenase | ADH_CLOBE | ADH3_SULSO | ADH1_ENTHI | 1DEH | different | ||
| (EC1.1.1.2) | DHSO_BACSU | — | ALDX_HUMAN | 2ALR | |||
| Formate dehydrogenase | FDHF_ECOLI | FDHA_METFO | — | 1FDI | different | ||
| (EC1.2.1.2) | FDH_PSESR | A64427 | FDH_NEUCR | 2NAD | |||
| Dihydrofolate reductase | DYRA_ECOLI | DYR_HALVO | DYR_HUMAN | 1DHF | different | ||
| (EC1.5.1.3) | DYR2_ECOLI | — | — | 1VIE | |||
| Peroxidase | — | — | PERM_HUMAN | 1MHL | same, | ||
| (EC1.11.1.7) | — | — | PER1_ARAHY | 1ARV | RMSD = 4.8 | ||
| Chloroperoxidase | PRXC_PSEPY | — | — | 1BRO | different | ||
| (EC1.11.1.10) | — | — | PRXC_CALFU | 1CPO | different | ||
| — | — | PRXC_CURIN | 1VNC | ||||
| Superoxide dismutase | SODC_ECOLI | — | SODC_HUMAN | 1SPD | different | ||
| (EC1.15.1.1) | SODF_ECOLI | SODF_SULAC | SODM_HUMAN | 1ABM | |||
| Protein-tyrosine phosphatase | PTPA_STRCO | — | PPAC_BOVIN | 1PHR | different | ||
| (EC3.1.3.48) | YOPH_YEREN | — | PTN1_HUMAN | 2HNP | |||
| Cellulase | GUNA_CLOCE | — | GUNB_NEOPA | 1EDG | different | ||
| (EC3.2.1.4) | GUND_CLOTM | — | GUN_PHAVU | 1CLC | different | ||
| — | — | GUN1_TRIRE | 1CEL | ||||
| Xylanase | XYNA_STRLI | — | S43846 | 1XAS | different | ||
| (EC3.2.1.8) | XYNA_BACCI | — | XYN2_TRIRE | 1XNB | |||
| Chitinase | CHIA_SERMA | — | CHIT_BRUMA | 1CTN | different | ||
| (EC3.2.1.14) | YE15_HAEIN | — | CHI1_ORYSA | 2BAA | |||
| β-Galactosidase | BGAL_ECOLI | — | BGAL_KLULA | 1BGL | different | ||
| (EC3.2.1.23) | BGLA_THEMA | BGAM_SULSO | BGLC_MAIZE | 1GOW | |||
| Lichenase | GUB_BACLI | — | YG46_YEAST | 1GBG | different | ||
| (EC3.2.1.73) | GUB_BACCI | — | 1CEM | different | |||
| — | — | GUB2_HORVU | 1GHR | ||||
| β-Lactamase | AMPC_ENTCL | — | — | 2BLT | different | ||
| (EC3.5.2.6) | BLAB_BACFR | — | — | 1ZNB | |||
| Fructose 1,6-bisphosphate | ALF_ECOLI | — | ALF_YEAST | 1DOS | same, | ||
| aldolase (EC4.1.2.13) | ALF_STACA | — | ALFA_HUMAN | 1FBA | RMSD = 3.4 | ||
| Carbonic anhydrase | CCMM_SYNP7 | CAH_METTE | — | 1THJ | different | ||
| (EC4.2.1.1) | — | — | CAH1_HUMAN | 2CBA | |||
| Peptidyl-prolyl isomerase | FKBX_ECOLI | FKB1_METJA | FKBP_HUMAN | 1FKD | different | ||
| (EC5.2.1.8) | CYPB_ECOLI | — | CYPB_HUMAN | 2CPL | |||
| Chorismate mutase | PHEA_ECOLI | Y246_METJA | CHMU_YEAST | 1ECM | different | ||
| (EC5.4.99.5) | CHMU_BACSU | — | — | 1COM | |||
| DNA topoisomerase I | TOP1_ECOLI | TOPG_SULAC | TOP3_YEAST | 1ECL | different | ||
| (EC5.99.1.2) | — | — | TOP1_YEAST | 1OIS | |||
[i] The full version of the table, including homologs of the enzymes found in each of the sequenced genomes, is available as a WWW supplement at http://ncbi.nlm.nih.gov/Complete_Genomes.
[ii] The proteins are listed under their SwissProt, GenBank, or Protein Data Base identifiers. The names of enzymes with experimentally demonstrated activity, shown in the first column, are in boldface type; the dash indicates absence of homologs in any of the sequenced genomes.
[iii] The data are from SCOP [http://scop.mrc-lmb.cam.ac.uk/scop(Hubbard et al. 1997)] and FSSP [http://www2.ebi.ac.uk./dali/fssp/fssp.html (Holm and Sander 1996a)] databases. RMSD of superimposed Cα atoms in the structural alignment of the two isoforms is from the FSSP database (Holm and Sander 1996a).