Summary of Pericentromeric-Directed Duplications in Man
| Segment | Ancestral locus | Duplicated loci | Est. length (kb) | Est. age (mya) |
| Adrenoleukodystrophy | Xq28 | 2p11, 10p11, 16p11, 22q11 | 9.7 | 5–7 |
| Creatine transporter | Xq28 | 16p11* | 26.5 | 5–7 |
| ERY-1/MN7 | 15q13 | 15q11*, 16p11* | ∼26 | 5–10 |
| KGFlocus | 15q15/21q21.1 | 2q21, 9p11, 9q12, 18p11, 18q11, 21q11 | ? | 5–10 |
| Glutamyl transpeptidase | 22q11.2 | 22q11*, 18, 19 and 20 | ? | ∼5 |
| MS29segment | 6p25 | 16p11* | ∼15 | 1–3 |
| Neurofibromatosis | 17q11.2 | 12q12, 14q11, 15q11, 18p11, 21q11, 22q11 | 1–4.6 | 1–25 |
| Variable IG heavy | 14q32.3 | 15q11 and 16p11 | ? | <5 |
| Variable IG κ | 2p11 | 1q12, 9p11, 9q11, 22q11 | 10–30 | 5–15 |
| Variable IG λ | 22q11 | 8q11 | ? | ? |
| von Willebrand factor | 12p12 | 22q11 | ∼30 | ∼5 |
[i] (*) Multiple copies of the segment are present within this region. (KGF) Keratinocyte growth factor gene; (ERY-1) END repeat family of transcripts; (IG) immunoglobulin gene segment. Estimated age (in mya) is based on divergence from ancestral sequence (this value may change as more copies of each duplicated segment are identified). Sequence divergences range from 10% to <1%. In many cases, the precise size of the duplication is undetermined.