Table 4.

Systolic Blood Pressure by Genotype for Putative QTLs in the F2(S × LEW) Population Raised on an 8% NaCl Diet

Chromosome Locus Genotype One-way ANOVA (P)
SS LS LL
1SA201.0 ± 5.21184.7 ± 4.55176.7 ± 3.190.0038
1D1Mco1205.6 ± 6.34185.9 ± 3.54175.2 ± 5.620.0006
2D2Mco19174.5 ± 4.26188.6 ± 4.04202.0 ± 6.370.0026
3D3Mgh6200.4 ± 6.53178.2 ± 3.35197.6 ± 5.800.0011
5Edn2200.4 ± 5.76193.0 ± 4.40169.0 ± 2.970.0001
7[ii] D7Mit5178.4 ± 4.3186.9 ± 4.3199.0 ± 5.90.052
8D8Wox2195.5 ± 5.66190.1 ± 4.15175.8 ± 4.940.039
10D10Wox6212.7 ± 7.00183.9 ± 3.62177.3 ± 4.36<0.0001
16D16Wox11202.3 ± 6.23186.9 ± 4.01176.8 ± 4.470.0051
17Hith187.3 ± 4.61196.1 ± 4.28168.9 ± 4.730.0014
18D18Mit4203.1 ± 6.71189.5 ± 4.51178.3 ± 4.200.016

[i] Means ± s.e. for systolic blood pressure (mmHg) are given by genotype at representative loci in the QTL regions identified in Table 3. All of these representative loci were typed on 151 rats. Differences of blood pressure among genotypes were analyzed by one-way ANOVA. (S) S rat allele: (L) Lew rat allele.

[ii] Detection of a possible blood pressure QTL on chromosome 7 is based on heart weight data (see Fig. 2, Table 5, and the text).