Table 2.

Types of Molecular Homology

HomologGenes that are descended from a common ancestor (e.g., all globins)
OrthologHomologous genes that have diverged from each other after speciation events (e.g., human β- and chimp β-globin)
ParalogHomologous genes that have diverged from each other after gene duplication events (e.g., β- and γ-globin)
XenologHomologous genes that have diverged from each other after lateral gene transfer events (e.g., antibiotic resistance genes in bacteria)
Positional homologyCommon ancestry of specific amino acid or nucleotide positions in different genes