Number of Families Required to Detect Linkage Disequilibrium for Sibships with r Affected Sibs Compared with Two Unrelated Controls Using Pooling
| r= 1 | r = 2 | r = 3 | r = 4 | |
| Dominant | ||||
| p = 0.05 | 207 | 66 | 36 | 27 |
| p= 0.20 | 158 | 73 | 51 | 42 |
| p = 0.70 | 2,204 | 1,158 | 819 | 656 |
| Recessive | ||||
| p = 0.05 | 28,820 | 5,015 | 1,325 | 431 |
| p = 0.20 | 712 | 154 | 55 | 26 |
| p = 0.70 | 160 | 72 | 49 | 39 |
| Multiplic. | ||||
| p = 0.05 | 872 | 265 | 121 | 66 |
| p = 0.20 | 300 | 102 | 52 | 32 |
| p = 0.70 | 352 | 152 | 93 | 67 |
| Additive | ||||
| p = 0.05 | 502 | 154 | 74 | 45 |
| p = 0.20 | 238 | 90 | 52 | 36 |
| p = 0.70 | 530 | 231 | 141 | 100 |