Table 1.

Phylogenetic Distribution of Eukaryotic-Type Protein Kinase Homologs

ABC1 RIO1 piD261 AQ578 PKN2 Other kinases FHA dom. PP2c phos.
Aquifex aeolicus AQ578AQ5762
Bacillus subtilis YbdMYabT[i]
YlopPYrzF[ii] 4
Mycobacterium MTCY10H4.14cMTCY04C12.28
 tuberculosis MTCY10H4.15cMTV013.01c
MTCY20H10.28cMTCY49.28MTCY04C12.30
MTV014.41MTCY50.16MTCY22G10.06c62
MTCY08C9.08MTCY338.02c
MTV021.09
Mycoplasma genitalium MG1091
Mycoplasma pneumoniae K04_orf3891
Chlamydia trachomatis Pkn1PknD
Pkn512
Borrellia burgdorferi
Treponema pallidum 3
Escherichia coli RfaY
YigR[iii] RfaP
InaA
Haemophilus influenzae HIN1393[iv]
Helicobacter pylori HP04321
Synechocystissp.slr1919sll1574/sll1575[v] slr0152slr0868[vi]
slr0889slr1225sll0776
sll0095slr1443slr0599107
sll0005slr1697
sll1770
Archaeoglobus fulgidus AF1804AF0665AF0418
AF2426
Methanobacterium MTH1645MTH1005MTH1425MTH915
 thermoautotrophicum
Methanococcus jannaschii MJ0444MJ1130MJ1211[vii]
MJ1073
Pyrococcus horikoshii PHBG027PHCJ009PHLF001
PHBQ051
Saccharomyces YGL119WYOR119CYGR262C
 cerevisiae YLR235WYNL207W116[viii] 159
YPL109C
Caenorhabditis CE09076CE00420
 elegans CE01198est_Celegans[ix] ∼400[x] 79

[i] The SWISSPROT version of this protein sequence (P37562) selects an upstream start codon adding 42 residues at the amino terminus, which includes homology to conserved region I of the ePKs.

[ii] This ORF appears to be a fragment of a protein kinase gene containing homology to conserved regions I, II, and III.

[iii] A correction of the original E. colisequence has joined the YigQ, YigR, and YigS ORFs into this single ORF.

[iv] This ORF was not annotated in the originalH. influenzae sequence (Koonin 1997).

[v] This appears to be a single ORF that has been split by a frameshift. For the purposes of this analysis, the two ORFs were simply fused.

[vi] This ORF appears to be a fragment of a protein kinase gene containing homology to conserved regions I and II of the ePKs.

[vii] See legend to Fig. 1 for a description of this sequence.

[viii] Our analysis of the “typical” protein kinases in yeast agrees with that of Hunter and Plowman (1997), with two additions. Specifically, we have included YJL057C and YGL083W. Examination to the sequence of YGL083W suggests it may be inactive, but it is clearly related to the ePKs.

[ix] See legend to Fig. 1 for a description of this sequence.

[x] This estimate is for those sequences present in the Wormpep 13 database, which contains ∼85% of the completeC. elegans genome.