The co-occurrence of mutations in CLL driver genes in BTK-mutated subclones
| Patient ID | CLL mutations co-occurring with BTKC481S | CLL mutations were present before BTKC481S developed | BTK-mutated subclone was dominant subclone at relapse |
|---|---|---|---|
| 1 | ASXL1, SF3B1, KMT2D, CREBBP | Yes | Yes |
| 2 | BRAF, SAMHD1, BCOR, NFKBIE, EGR2 | Yes | Yes |
| 3 | DICER1 | No | Yes |
| 4 | TP53 | Yes | No |
| 5 | NOTCH1 | Yes | Yes |
| 6 | SF3B1, POT1 | Yes | No |