The developmental time point presenting the highest fold-change of either upregulation or downregulation of mtDNA gene expression in samples from Data sets I and II
| Before P0 | Right after birth/hatching | First week/s after birth | Late change | |
|---|---|---|---|---|
| Heart | — | Human (0.87), mouse (0.88), rat (0.72), rhesus (0.86), chicken (0.66) | Rabbit (0.83) | — |
| Forebrain/cerebrum | Chicken (0.35) | Human (0.72), rat (0.06), rhesus (0.65) | Mouse (0.37), rabbit (0.59) | — |
| Hindbrain/Cerebellum | — | Human (0.62), rat (0.19), rhesus (0.41), chicken (−0.19) | Mouse (0.69), rabbit (0.52) | — |
| Kidney | Human (0.78), mouse (0.84), rhesus (0.88) | Chicken (0.16), rat (0) | Rabbit (0.79) | |
| Liver | Human (0.23), pig (0.8), rat (0.03) | Chickena (−0.6), mouse (0.67), rabbit (0.27) | Rhesus (0) | |
| Testis | Human, rabbit, rata | Chicken,a rhesus | Mousea | |
| Ovary | Chicken,a rabbit, rata |
[i] aDownregulation; the rest were upregulated. Numbers in parentheses indicate the level of coordination of nuclear DNA–encoded OXPHOS genes and mtDNA-encoded genes as explained in the Methods.