Binding site accessibility is a key determinant of TP53 family–nucleosome binding. (A) Measuring library-nucleosome accessibility via MNase digestion, represented by MNase-digestion scores. (Edge) The left or right end of the canonical 146 bp nucleosome core particle. (B–D) Correlating TP53, TP63, or TP73 binding strength with binding-site accessibility (measured by MNase-digestion scores). Shading around regression lines represents 95% confidence intervals.