Benchmarking performance of geneCover and competing methods on the DLPFC data set. To obtain the geneCover marker panel, we apply Iterative-GeneCover in Algorithm 1 with parameters: {k_t}_1:T = {100, 100, 100, 100, 100}, m = 3. (A) NMI versus the size of the marker gene panel for all label-free methods. (B) Manually annotated histological layers of the DLPFC. (C) Leiden clusters obtained using 500 genes selected by each method with the same random seed. (D) Expression of selected marker genes from geneCover.