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Table 1.

Inputs for the different methods evaluated

Method	BOLT/GCTA-GREML, RHE	SUM-RHE	LDSC	SumHer
Inputs	Individual genotype	Ref. trace	Ref. LD scores	Ref. SNP tag
Inputs	Individual phenotype	GWAS summary	GWAS summary	GWAS summary

[i] LDSC and SUM-RHE rely only on the summary statistics, whereas GCTA-GREML, BOLT-REML, and RHE require individual data for target genotypes and phenotypes.