Table 1.

Replication of TRs previously associated with Alzheimer's disease

TRs previously associated with AD
RegionChr 19:44921096–44921134Chr 11:47775208–47775243Chr 19:1049436–1050066Chr 14:52832909–52832938
GeneAPOC1SPI1ABCA7FERMT2
Best modelJoint allelesShort allelesJoint allelesShort alleles
Beta (OR)0.38 (1.46)−0.03 (0.97)8.63 × 10−5 (1.01)0.01 (1.01)
P-value2.6 × 10−96.5 × 10−30.0410.27
Original study38014121377455452958909737745545
Original ORNA−0.01 (0.99)4.50.01 (1.01)
Original modelLonger alleleJoint allelesIndividuals with alleles >5720 bpJoint alleles
Original methodLogistic regressionMixed linear modelsFisher's exactMixed linear models
Original P-value4.3 × 10−10NA0.008NA
Original samples1489 AD versus 1492 controls6328 AD versus 6580 controls275 AD versus 177 controls6328 AD versus 6580 controls
Data typeShort-read sequencingShort-read sequencingSouthern blotShort-read sequencing

[i] Region: genomic coordinates of the TR with respect to GRCh38; Gene: the closest gene as reported in the original publications; Best model: model that yielded the most significant association, in our comparison: short allele, long allele, or joint alleles size; Beta (OR): effect size and relative Odds Ratio with respect to AD: an increased TR size leads to increased AD risk for positive estimates; P-value: P-value of association. We used logistic regression models using TR size (short allele, long allele, and combined allele size) as predictor for AD case-control status, using 246 AD patients (cases) and 248 cognitively healthy centenarians (controls); Original study: the PubMed ID of the original study; Original OR: the odds ratio as reported in the original study; Original model: model used for association in the original study; Original method: method used for association in the original study; Original P-value: the P-value reported in the original study; Original samples: the number of AD cases and controls used in the original study; Data type: the data on which the association were identified.

[ii] (TR) Tandem repeat, (AD) Alzheimer's disease.