Epigenomic signatures and chromatin interactions are tightly related to transcriptional regulation. (A) Landscape of chromatin accessibility and histone modifications in the silkworm genome. (B) Enrichment of chromatin accessibility and histone modifications around all the 16,880 transcription start sites (TSSs) in the silkworm genome. (C) Landscape of significant cis-interactions in the genome. (FIRE) Frequently interacting regions. (D) Average interaction frequency around all the 16,880 TSSs. (E) Enrichment of the significant interacting regions on indicated genomic features, including the promoter, 5′ untranslated region (5′ UTR), 3′ untranslated region (3′ UTR), exon, intron, and intergenic region.