Precision environmental health network revealed by inter-omics analyses between the exposome and internal multi-omics. (A) Spearman's correlation network of all longitudinally profiled exposome and internal -omes. (B) Significant Spearman's correlations between the exposome and the internal multi-omics (|r| > 0.9; Q-value < 0.05). (C) Spearman's correlation analysis between the individual's exposome and the gut microbiome. Only gut bacteria with degrees > 20 are shown, and the highest-degree bacteria are named. The complete network is provided in Supplemental Figure S4C. (D) Heat map of the highest-degree personal gut bacteria and significant correlations with the exposome components (|r| > 0.9; Q-value < 0.05). Additional high-degree gut bacteria are provided in Supplemental Figure S4D.